肝病

炎症和代谢指标可预测肝癌风险

作者:佚名 来源:爱唯医学网 日期:2017-07-09
导读

         该项前瞻性、巢式病例对照研究主要评估了炎症和代谢指标与肝癌(主要是肝细胞癌)发生风险之间的关系。在研究中,共有125例患者在平均7.7年的随访期间发生HCC。

关键字:  肝癌 

        该项前瞻性、巢式病例对照研究主要评估了炎症和代谢指标与肝癌(主要是肝细胞癌)发生风险之间的关系。在研究中,共有125例患者在平均7.7年的随访期间发生HCC。校正吸烟、饮酒、饮咖啡、受教育程度、糖尿病、体重指数、HBsAg和抗-HCV感染情况、以及腰高比等因素后发现,患者C反应蛋白、白介素-6、C肽和非高分子量脂联素水平每升高1倍, HCC的发病率比值(IIR)分别为1.22,1.90,2.25和2.09。此外,谷氨酸脱氢酶(一个肝组织炎症指标)水平升高也与HCC风险增加有关。

        该研究提示,炎症指标(尤其是胰岛素抵抗和内脏肥胖指标)可能与肝癌风险增加有关。

        TAKE-HOME MESSAGE

        This study used a prospective, nested, case-control design to evaluate the association of inflammatory and metabolic markers with the risk for developing liver cancer, mostly hepatocellular carcinoma (HCC). In this study, 125 patients developed HCC over an average of 7.7 years of follow-up. Adjustments were made for factors such as smoking, alcohol intake, coffee intake, education, diabetes, body mass index, HBsAg/anti-HCV infection, and waist-to-height ratio. Significant incidence rate ratios (IRR, per doubling of concentration) for HCC were found for C-reactive protein (IRR = 1.22), interleukin-6 (IRR = 1.90), C-peptide (IRR = 2.25), and non–high molecular–weight adiponectin (IRR = 2.09). Higher levels of glutamate dehydrogenase, a marker of liver inflammation, were also associated with higher risk for HCC.

        Inflammatory markers, and especially markers of insulin resistance and visceral adiposity, appear to be associated with a higher risk for liver cancer.

        Inflammatory and Metabolic Biomarkers and Risk of Liver and Biliary Tract Cancer

        Hepatology 2014 Sep 01;60(3)858-871, K Aleksandrova, H Boeing, U Nöthlings, M Jenab, V Fedirko, R Kaaks, A Lukanova, A Trichopoulou, D Trichopoulos, P Boffetta, E Trepo, S Westhpal, T Duarte-Salles, M Stepien, K Overvad, A Tjønneland, J Halkjaer, MC Boutron-Ruault, L Dossus, A Racine, P Lagiou, C Bamia, V Benetou, C Agnoli, D Palli, S Panico, R Tumino, P Vineis, B Bueno-de-Mesquita, PH Peeters, IT Gram, E Lund, E Weiderpass, JR Quirós, A Agudo, MJ Sánchez, D Gavrila, A Barricarte, M Dorronsoro, B Ohlsson, B Lindkvist, A Johansson, M Sund, KT Khaw, N Wareham, RC Travis, E Riboli, T Pischon

        From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

        This abstract is available on the publisher's site.

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